Beilstein J. Org. Chem.2009,5, No. 69, doi:10.3762/bjoc.5.69
place to afford cis-2,4-diaryl-substituted pyrrolidines 35–37.
Keywords: cyclic sulfonamides; diastereoselectivealkenefunctionalisation; double reduction; Pd-mediated cross coupling; Introduction
Substituted pyrrolidine ring systems represent a common structural motif in a range of biologically
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Graphical Abstract
Scheme 1:
The diastereoselective intramolecular Heck-hydrogenation and double reduction sequence as a means o...